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LABORATORY TESTS No specific laboratory tests are deemed essential for the management of patients on LIORESAL INTRATHECAL.

An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactionseither prior to screening or following implant and initiation of chronic LIORESAL INTRATHECAL infusionReduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physicianAbrupt reduction or discontinuation of concomitant antispastics should be avoided.

On each occasion that the dosing rate of the pump and/or the concentration of LIORESAL INTRATHECALbaclofen injectionin the reservoir is adjustedclose medical monitoring is required until it is certain that the patient’s response to the infusion is acceptable and reasonably stable.

Lioresal is indicated for the relief of spasticity of voluntary muscle resulting from such disorders asmultiple sclerosisother spinal lesionse.gtumours of the spinal cordsyringomyeliamotor neurone diseasetransverse myelitistraumatic partial section of the cord.

LIORESAL INTRATHECALbaclofen injectionis indicated for use in the management of severe spasticityPatients should first respond to a screening dose of intrathecal baclofen prior to consideration for long term infusion via an implantable pumpFor spasticity of spinal cord originchronic infusion of LIORESAL INTRATHECAL via an implantable pump should be reserved for patients unresponsive to oral baclofen therapyor those who experience intolerable CNS side effects at effective dosesPatients with spasticity due to traumatic brain injury should wait at least one year after the injury before consideration of long term intrathecal baclofen therapyLIORESAL INTRATHECAL is intended for use by the intrathecal route in single bolus test dosesvia spinal catheter or lumbar punctureandfor chronic useonly in implantable pumps approved by the FDA specifically for the administration of LIORESAL INTRATHECAL into the intrathecal space.

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